CDR3 SEQUENCE SIMILARITY ANALYSIS:   Baseline vs. Week 12
  1. Contracted clones

Summary statistics resulting from the CDR3 amino acid sequence similarity analysis that was performed to determine whether contracted clones after 12 weeks of TNFi are characterized by a higher sequence similarity than expected by chance.


Observed CDR3 amino acid sequence similarity networks at the chain level:








  1. Expanded clones

Summary statistics resulting from the CDR3 amino acid sequence similarity analysis that was performed to determine whether expanded clones after 12 weeks of TNFi are characterized by a higher sequence similarity than expected by chance.


Observed CDR3 amino acid sequence similarity networks at the chain level:









CDR3 SEQUENCE SIMILARITY ANALYSIS:   Baseline vs. Week 12 in responders to TNF inhibition therapy
  1. Contracted clones

Summary statistics resulting from the CDR3 amino acid sequence similarity analysis that was performed to determine whether contracted clones detected in responders to TNFi are characterized by a higher sequence similarity than expected by chance.


Observed CDR3 amino acid sequence similarity networks at the chain level:








  1. Expanded clones

Summary statistics resulting from the CDR3 amino acid sequence similarity analysis that was performed to determine whether expanded clones detected in responders to TNFi are characterized by a higher sequence similarity than expected by chance.


Observed CDR3 amino acid sequence similarity networks at the chain level:









CDR3 SEQUENCE SIMILARITY ANALYSIS:   Baseline vs. Week 12 in non-responders to TNF inhibition therapy
  1. Contracted clones

Summary statistics resulting from the CDR3 amino acid sequence similarity analysis that was performed to determine whether contracted clones detected in non-responders to TNFi are characterized by a higher sequence similarity than expected by chance.


Observed CDR3 amino acid sequence similarity networks at the chain level:








  1. Expanded clones

Summary statistics resulting from the CDR3 amino acid sequence similarity analysis that was performed to determine whether expanded clones detected in non-responders to TNFi are characterized by a higher sequence similarity than expected by chance.


Observed CDR3 amino acid sequence similarity networks at the chain level:








 

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